Programs that don't work under the MSDOS Emulator and probably won't ever work, because of fundamental problem. Some of these fundamental problems result in these programs not being runnable on Win3.x/Win95/WinNT in a Dosbox and under OS/2 either. These programs are characterized by using any of these features:
VCPI allows programs to run in ring 0. This is kernel mode in Linux and not sensible.
Example: sim2181.exe from Analog Devices DSP Kit
The Pharlap Extender in it's older versions needed ring 0 access too, so it can't me made working in the emulator.
Example:Autocad Version 12c1 For DOS
krnl386.exe needs Ring 0 access too.
Win32s needs Ring 0 access too.
Check with "strings <program.exe> | less" if the programm contains some of these keywords vcpi, pharlap and win32s. Newer Pharlap programs may work.